الفهرس 
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Abstract
Improving patient safety, reducing and preventing central line -related infection especially in the intensive care unit are now a priority for hospitals. Therefore; nurses play an integral role in preventing infections. Aim of the study: the aim of this study was to examine the effect of implementing guidelines for prevention of central line infection on nurses’ knowledge and practice. Setting: The present study was conducted in intensive care unit of New Surgical Hospital affiliated to Zagazig University Hospitals. Sample: The study sample was included 40 nurses who are working in the above mentioned setting. Tools: Two tools were used for data collection which includes questionnaire sheet and observational checklist. Results: The study results revealed that prior to guidelines implementation; majority of nurses had unsatisfactory knowledge score and practice. In post guidelines, the findings pointed out to significant improvement. There was a statistically significant correlation between knowledge and practice score. Conclusion: Nurses’ knowledge and practice improve after implementation of the guidelines for prevention of central line infection. Recommendations: Provision of continuous education and guidelines for prevention of central line infection and further studies to examine the impact of guideline on patients’ outcomes are required.