الفهرس 
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Abstract
Liver has a prominent role in the regulation of physiological processes. It is involved in varieties of vital functions such as metabolism, secretion and storage. Furthermore, detoxification of a variety of drugs and xenobiotics occurs in liver. Hence liver diseases are among the most serious health problems. They may be classified as acute or chronic hepatitis (inflammatory liver diseases), hepatosis (non-inflammatory diseases) and cirrhosis (degenerative disorder resulting in fibrosis of the liver). Liver diseases are mainly caused by toxic chemicals (certain antibiotics, chemotherapeutics, peroxidised oil, aflatoxin, carbon-tetrachloride, paracetamol, chlorinated hydrocarbons, etc.), excess consumption of alcohol, infections and autoimmune disorder.
Recently, Mesenchymal stem cells show ability to differentiate into hepatocytes, stimulate the regeneration of endogenous parenchymal cells and enhance fibrous matrix degradation.
Thus the aim of this study was to investigate the effect of injection of bone marrow (BM)-derived MSCs on the experimental liver fibrosis and cirrhosis in rats.
Methods:
Animal model of liver fibrosis and cirrhosis was induced by subcutaneous injection of CCl4 at a dose of 0.2 mL/100 g.