الفهرس 
ABSTRACT
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Abstract
Sustained or prolonged release tablets are compressed tablets especially designed to release the drug over a long period of time. The development of sustained-release formulations continues to be a great success for the pharmaceutical industry with much interest being shown by academic research. The marketing of oral modified drug delivery alone is expected to grow more and more throughout the coming years. The sustained release formulations offer many advantages over conventional dosage forms. They are proved to increase patient compliance, reduce adverse effects, improve tolerability, increase therapeutic advantage and reduce healthcare cost.
Different technologies have been proposed for manufacturing oral sustained-release tablets. The basic approaches have remained largely unchanged for preparation of sustained release tablets, with the major systems being (a) insoluble, slowly eroding, or swelling matrices, (b) polymer-coated tablets (c) osmotically driven systems, (d) systems controlled by ion exchange mechanisms, and (e) various combinations of these approaches. However, extended matrix systems remain to be a more practical choice for preparation of extended release tablet formulation. These systems provide reliable as well as reproducible release profiles in-vitro and in-vivo. The scientific literature is full of other intricate and complex examples of oral modified-release systems, but the commercial applicability and success of many of these systems/devices has yet to be realized.
Matrix tablets are considered as the most reliable and applicable technology to achieve sustained therapeutic action of drugs. However, oral sustained relearelease (SR) matrix.