الفهرس 
Neonatal SepsisOnly 14 pages are availabe for public view
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Abstract
Neonatal sepsis is a clinical syndrome of bacteremia characterized by systemic signs andsymptoms of infection in the first month of life.
Ciprofloxacin is a safe therapeutic option for newborns with sepsis produced by multiply resistant organisms. The use of ciprofloxacin is animportant therapeutic advance because of its broad antibacterialspectrum, bactericidal effect at therapeutic dosesand good penetration of the cerebrospinal fluid.
However,the potential to cause irreversible damage to cartilage inweight-bearing joints in miniature animals has largelyrestricted the use of ciprofloxacin in the pediatric age.
MMP-3 is not expressed in normal tissue,but is rapidly induced in cases of tissue repair or during remodelingprocesses MMP-3 has been previouslyshown to be over expressed in OA given their important role in cellular functions.
The aim of this work was to evaluate the adverse effects of ciprofloxacin treatment of neonatal sepsis (if any): hepatic, renal, hematological, and especially its arthropathogenic effect.
The study included 45 neonates were divided into 3 groups:20 neonateswith septicemia treatment group who received ciprofloxacin in a dose of 20 mg/kg in two divided doses as a slow intravenous infusion over a period of 30 minutes, for a period of 14 days;15 neonates with septicemia who did not receive ciprofloxacincontrol groupand 10 stable healthy neonates.
All neonate groups were subjected to laboratory investigations as Hb, TLC,CRP,blood culture,Plt,PT,PTT,AST,ALT,ALP,S.K,S.Mg,S.Ca,S.Na,S.Creat.,BUN,S.Bilirubin, S.MMP-3 and radiological investigation as ultrasonography evaluation of the right knee jointanteroposterior, cranicaudal and transverse diameter and longitudinal and transverse area of the lower end of femur and upper end of tibia; ”two layer” appearance of the cartilage ,fluid in the suprapatellar bursa; and contour of the epiphyses.
As regard demographic characteristics, clinical characteristics, laboratory characteristics (baseline) and laboratory characteristics after 14 days of 3 studied groups showed no significant differences,however, Apgar score at 1 min, chest examination, TLC, CRP and blood culture showed significant differences.
On comparing Laboratory characteristics of treatment group measured baseline to after 14 days, significant decreasewas found regarding TLC, Hb and CRP after 14 days but no significant difference regarding other parameters.
As regard ultrasonographic findings of right knee (femur and tibia) of 3 studied groupsbaseline showed no significant increase in size of cartilage in follow up denoting growth of cartilage however, ultrasonographic findings of right knee(femur and tibia) of 3 studied groupsafter 14 days showed significant difference regarding AP diameter and TR area respectively.
As regard ultrasonographic findings of right knee (tibia and femur) in 3 studied groups baseline and after 14 days showed significant difference regarding CC diameter, AP diameter,TR diameter,Long. Area and TR. Area due to increasing age of baby but no significant difference regarding the rest of parameters.
Correlation between MMP-3 and other laboratory investigations baseline and after 14 days did not show any significant difference.
Correlation between MMP-3 and ultrasonographic findings of right knee femur and tibia baseline and after 14 daysdid not show any significant difference.