الفهرس Only 14 pages are availabe for public view
 |  | from | 110 |  |  |
| | | from | 110 | | |
Abstract
Acute liver impairment is a rare but life-threatening critical illness that occurs most often in patients who do not have preexisting liver disease. Hepatitis A virus infection (HAV) is the commonest cause of acute liver damage, especially in overcrowded countries like Egypt with an increased prevalence and a particularly poor prognosis following HAV superinfection of patients with HCV infection. Changes in liver function can affect the body’s response to drugs due to both PK and PD changes. These changes can lead to a number of outcomes including reduced or enhanced therapeutic effects and/or excessive side effects. The effect of acute liver impairment on the PD of aspirin, clopidogrel and prasugrel is not well defined yet. In our current study the PD of these drugs were assessed by measuring the platelet aggregation using light transmission aggregometry, which is the gold standard test for detecting platelets function.
In the present study, a rat model of TAA induced acute liver damage was used to assess and compare the effect of acute liver impairment on the pharmacodynamics of antiplatelet drugs; Aspirin, Clopidogrel and Prasugrel. The study was conducted on 128 male rats weighing 150-200 gm. Animals were randomly assigned into the following groups:
group I: Consisted of 8 rats which served as normal control group, they received the vehicle solution (0.9% NaCl, i.p) this was followed by the administration of 1ml of 2% gum acacia orally daily for 14 days.
group II: Consisted of 8 rats served as the diseased model group in which acute liver injury was induced by single i.p injection of TAA (300 mg/ kg body weight freshly dissolved in 0.9% NaCl).
group III: was further subdivided into:
• GIII-a: Consisted of 8 rats that received oral clopidogrel (30mg/kg/day) suspended in 2% gum acacia daily for14 days.
• GIII-b: Consisted of 8 rats that received TAA (300 mg/ kg, i.p) freshly dissolved in 0.9% NaCl on 1st day and oral clopidogrel (30mg/kg/day) suspended in 2% gum acacia daily for 14 days.
group IV: was further subdivided into:
• GIV -a: Consisted of 8 rats that received oral aspirin (15mg/kg/day) suspended in 2% gum acacia for daily 14 days.
• GIV- b: Consisted of 8 rats that received TAA (300 mg/ kg, i.p) freshly dissolved in 0.9% NaCl on 1st day and oral aspirin (15 mg/kg/day) suspended in 2% gum acacia daily for 14 days.
group V: was further subdivided into:
• GV-a: Consisted of 8 rats that received oral prasugrel (3mg/kg/day) suspended in 2% gum acacia daily for 14 days.
• GV-b: Consisted of 8 rats that received TAA (300 mg/ kg, i.p) freshly dissolved in 0.9% NaCl on 1st day and oral prasugrel (3mg/kg/day) suspended in 2% gum acacia daily for 14 days.