الفهرس | Only 14 pages are availabe for public view |
Abstract Quinoline, thiadiazole, thiazole and thiazolidine derivatives occupy a wide space biologically active molecules in the fields of anti-inflammatory, analgesic, antioxidant, antimicrobial, antitumor, antiviral, antimalarial and antiparasitic activities. This fact motivated our interest in the present investigation to design and synthesize new compounds comprising quinoline bearing various thiadiazole, thiazoline and thiazolidine moieties through different linkage. The newly synthesized compounds were screened for their antibacterial, antifungal and antioxidant activities. The work done in the present thesis can be classified as follows: Chapter 1: Introduction: This chapter presented a brief literature survey on some biologically active quinoline, thiadiazole, thiazole and thiazolidine isolated or combined compounds exhibiting anti-inflammatory, antimicrobial, antioxidant, antimalarial, antiamebic, antiviral, antileishmanial, antitubercualer and anticancer activities. Chapter 2: Research objectives: Regarding the antimicrobial and antioxidant activities of different quinolines, this chapter deals with the aim of the work and the rationale upon which the new compounds have been synthesized to study their antimicrobial and antioxidant activities. Chapter 3: Discussion: This section deals with the theoretical concept of the methods adopted for the synthesis of the designed compounds with reference to the knowledge available in the literature and structural elucidation by various spectral data. |