الفهرس 
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Abstract
Hodgkin lymphoma (HL) accounts for 8% to 10% of all childhoo cancer. It displays characteristic epidemiological, clinical, and pathological features according to various geographic areas. We aimed to assess the epidemiological aspects, clinicopathological features, and treatment outcome of pediatric HL treated at Pediatric Oncology Department,National Cancer Institute, Cairo University.We carried a retrospective study by reviewing medical records for all patients admitted with the diagnosis of HL over 5 years during the period between January 2008 till end of December 2012, and they were followed up till the end of December 2013.Age of the patients at presentation ranged from 3 to 18 years(median 11 years) and male: female ratio 1.6:1. Cervical lymphadenopathy was the most common presentation (94.8%). Mixed cellularity subtype was dominant (44.7%), followed by nodular sclerosis (34.3%), lymphocyte-rich10.4%) with lymphocyte depletion being the least dominant (3.7%). About half of patients (45.5 %) had advanced disease (Ann Arbor stage III/IV disease). The duration of follow-up ranged from 6 to 56.5 months (median 35.8 months). The 5-year overall survival and event-free survival for patients were 94% and 79% respectively.In Egypt, HL occurs in young age group, with a higher incidence of mixed cellularity subtype and advanced disease. Pretreatment factors including high risk groups, higher stages, B symptoms, bulky disease, more than 3 groups of lymph nodal involvement, presence of 2 or more risk factors were associated with inferior EFS and outcome. The overall and event-free survival of HL at National Cancer Institute, Egypt were satisfactory and approaching the international percentage.Key Words: Pediatric Hodgkin’s Lymphoma- National Cancer Institute,Cairo University, Egypt.