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العنوان
Heterocyclization of cyclic carbonyl derivatives /
المؤلف
Abd El-Rahman, Hamdi Mohammed.
هيئة الاعداد
باحث / حمدي محمد عبد الرحمن
مشرف / محمد جمعة محمد عاص،
مناقش / احمد سعيد احمد يوسف
مناقش / وجدى ابراهيم الدجدج
مناقش / حامد يوسف مصطفى
الموضوع
Carbonyl compounds.
تاريخ النشر
2015.
عدد الصفحات
111 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
1/8/2015
مكان الإجازة
جامعة الزقازيق - كلية العلوم - قسم الكيمياء
الفهرس
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Abstract

The synthesis of condensed pyrimidinederivative4was achieved by refluxing of cyclopentanone1,thiourea 3and two equiv. of benzaldehyde2 in the presence of NaOH.The [3+3] cycloaddition of compound4and benzylidenemalononitrile6afford the pyrimidothiazine(7). Compound 4underwent epoxidation when it was reacted with H2O2 in the presence of acetic acid to give the epoxide 8. Alkylation of compound 4with ethyl iodide yielded the alkylated product 9.Compound cyclopentylidenemalononitrile10 was treated with phenylisothiocyanate 11to afford cyclopentylidenemalononitrile derivative 12. The compound 10 was added to the electrophilic carbon of activated benzoyl isothiocyanate 13 to give the condensed thiopyrane derivative15.Reaction of compound 10and Phenyl isocyanate 16 in basic medium afforded the cyclopentadiene derivative 17. Base induced [2+4] cycloaddition of carbon disulphide and compound 10 delivered thiopyran derivative19. Refluxing the cyclopentanone 1 with the ethylenic ketone 20 in the presence of a catalytic amount of dimethylamine, afforded the cyclopentanone derivative 21.The reaction of cyclic unsaturated nitrile 10 and formalin 22in the presence of HCl as a catalyst afforded cyclopentanopyridine derivative26.The treatment of cyclopentanone 1 with benzoyl isothiocyanate in the presence of dimethylamine afforded cyclopentanone derivative27.The trione compound 30 was synthesized by reaction of cyclic ketone 1 with benzoyl chloride in the presence of dimethylamine as a catalyst.