الفهرس 
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Abstract
CD36 is a membrane glycoprotein that is expressed mainly in hematopoietic cells in mononuclear cells.
The aim of study was to investigate the expression of CD36 in leukemia cells of myeloid origin , to explore its significance in diagnosis and differntial diagnosis for acute myeloid leukemia in patients and and to evaluate its association with the different clinical and laboratory data.
Blood and BM samples from 30 cases of newly diagnosed myeloid leukemias were analyzed by multi-color flow cytometry in order to determine the CD36 and other leukocyte differentiation antigens. The results show that the CD36 positive rate was 46.7% (14/30) in 30 cases of AML (acute myeloid leukemia).
The positive rate of CD36 was 100% in M4- M5 (14/14) was significantly higher than that in M1 (0/4), M2 (0/6), M3 (0/5) and M6 (0/1) (all P <0.001).
A significantly positive regression was found between CD36 and CD14 in M4-M5 (r = 0.87, P = 0.03).
In monocyte lineage involved leukemia (MLIL), the positive rate of CD36 (100%, 14/14) was significantly higher than that of CD15 (71.4%, 10/14) (P=0.001) and that of CD14 (64.3%, 9/14) (P = 0.001) .
The positive rate of CD15 was higher (71.4%, 10/14) in M4-M5 than CD14 (64.3%, 9/14).
CD36 expression was not associated with any the studied clinical or laboratory variables, except for platelet count and BM blasts percentage in acute myeloid leukemia patients .
Currently widely used internationally as a surface marker CD14 monocytes and applied immunological diagnosis of acute myeoid leukemia, but a lower rate of positive expression of CD14, which gives diagnosis and differential diagnosis of acute myeloid leukemia ,some difficulties.
CD14 is a specific feature of mature monocyte, but this antigen is frequently absent or underexpressed in other type of AML making CD36 a useful marker of monocytic differentiation in immature monocyte that lack CD14 expression.
It is concluded that the combination of CD36 with myeloid antigens is helpful to the diagnosis and differential diagnosis of myeloid and MLIL (monocyte lineage involved leukemia). The positive rate of CD36 is higher than that of CD14 in MLIL.
CONCLUSIONS
It is concluded that the combination of CD36 with myeloid antigens is helpful to the diagnosis and differential diagnosis of myeloid and MLIL (monocyte lineage involved leukemia). The positive rate of CD36 is higher than that of CD14 in MLIL.