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Abstract Cardiovascular complications are the leading cause of diabetes-related morbidity and mortality. Although, the most common cardiac manifestation in diabetic patients is coronary artery disease, heart failure (HF) is also a major cause of mortality and morbidity in patients with diabetes mellitus. Diabetic cardiomyopathy was first defined by Rubler in 1972, as ventricular dysfunction occurring independently of coronary artery disease (CAD) and hypertension. Diabetic cardiomyopathy describes diabetes-associated changes in the structure and function of the myocardium including myocellular hypertrophy, myocardial fibrosis, decreased or preserved systolic function in presence of diastolic dysfunction. |