الفهرس 
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Abstract
Part (I): Synthesis and antitumor activity of some new pyrazolo[3,4-d]-pyrimidine and pyrazolo[3,4-b]pyridine derivatives: 3-Methyl-1-thiocarbamoyl-2-pyrazolin-5-one has been utilized as an intermediate for the synthesis of some 1-(thiazol-2-yl)-pyrazolin-5-one derivatives through diazo-coupling reaction and/or Knoevenagel condensation followed by heterocyclization with some α-halogenated reagents such as bromoacetone, phenacyl bromide and ethyl bromoacetate. The base prompted addition of 1 to equimolar amount of phenyl isothiocyanate furnished 3-methyl-4-phenylthiocarbamoyl-1-thiocarbamoyl-2-pyrazolin-5-one which undergoes heterocyclization with α-halogenated reagents at the more reactive phenylthiocarbamoyl moiety to afford the corresponding 4-(thiazol-2-yl)-1-thiocarbamoyl-2-pyrazolin-5-ones. The new synthesized thiazolyl-pyrazolone compounds were evaluated for their potential antioxidant activity by using (ABTS Radical Cation Decolorization Assay). Part (II): Synthesis some new thiazolyl-pyrazole derivatives as antioxidants: Some new pyrazolo[3,4-d]pyrimidine-3-carbonitrile and pyrazolo[3,4-b]pyridine-3-carbonitrile derivatives were synthesized by the reaction of 5-amino-1-tosyl-1H-pyrazole-3,4-dicarbonitrile (2) as a key starting material with different electrophilic and nucleophilic reagents. All the newly synthesized compounds have been evaluated for their potential cytotoxicity against Larynx Epdermoid carcinoma (Hep2).