الفهرس 
EpidemiologyOnly 14 pages are availabe for public view
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Abstract
CRT remains the optimum treatment in cases with locally advanced HNCSS with better organ preservation, locoregional control ,distant metastasis control as well as overall and progression free survival. Induction chemotherapy has been incorporated with aim to improve treatment outcomes. In our study ,however, there was no difference in treatment outcome although number of patients was small and results were statistically in significant.
Platinum compounds have been used frequently as radiosensitizers.Inspite that cisplatin showed slight better response rates than carboplatin ,however 3 years-overall survival and progression free survival were comparable. As regard toxicity there was more mucositis seen withcarboplatin ,while in cisplatin showed more nephrotoxicity and vomiting in our study.
Toxicity observation and well management should be taken in consideration during and after completion of treatment course. Avoiding treatment interruptions is necessary for optimal treatment outcomes.