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Abstract The aim of the current study was: 1- The detection of vascular endothelial growth factor (VEGF), Interleukin 1 alpha (IL-1-α) and tumour necrosis factor alpha (TNF-α) from normal and irreversibly inflamed pulps from both healthy individuals and blood disordered patients (thalassemia and sickle cell anemia) by immunohistochemical method. 2- The correlation between the severity of the inflammation, and the amount of the inflammatory mediators and VEGF in blood disordered diseases (thalassaemia and sickle cell anaemia). |