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Abstract Buddleja is a genus of flowering plants, belongs to family Scrophulariaceae. The previous studies showed the importance of this species due to its biological activities and applications in traditional medicine and economic. Therefore, we decided to perform detailed phytochemical and biological studies on Buddleja asiatica. The fresh plant, aerial parts were steam distilled to give the essential oil, and the residual matter was successively extracted using the organic solvents petroleum ether, n-hexane, methylene chloride, ethyl acetate and finally butanol. and the study investigation of the volatile components of this species. The constituents of each fraction were investigated by chromatographic techniques (column and thin layer chromatography). This work has led finally to characterization of 88 natural compounds using modern spectral methods such as GC/MS and NMR spectroscopy. . It was a biological evaluation of plant extracts: 1. Evaluation antioxidant activity. 2. Evaluation antimicrobial activity. 3. Evaluation cytotoxicity against human tumor cells HePG2, MCF-7, HCT-116 and PC3. These organic compounds may have applications in the medical field, economic or academic interest. |