الفهرس 
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Abstract
Throughout this study, a screening for antitumor marine microbial producers occurred using seawater samples collected from different stations of the Western Harbour of Alexandria, the bioactivity detected and confirmed using different bioassays like economical technique known as the Red potato disc Bioassay (Hussain et al., 2007). Another conformational bioassay technique has been applied on the potent isolates called SulfoRhodamine B (SRB) assay using two cancer cell lines; colon cell line (HCT 116) and liver cell line (HepG2). Also, a comparison with a standard compound 5-flurouracil was investigated (El-Shatoury et al., 2009; Malaker and Ahmad, 2013; Li et al., 2013). The bio-toxicity of the potent supernatants was perforrmed using the biomarker Artemia salina (Niaz et al., 2013). Finally, the most potent isolate optimized to reach the ideal conditions for maximum bioactivity using a Plackett-Burman experimental design (Bashir et al., 2012).