الفهرس 
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Abstract
Aromatase is a key steroidogenic enzyme that catalyzes the synthesis of estrogens from androgens. Aromatase inhibitors (AIs) provide novel approaches to the adjuvant therapy for postmenopausal women with estrogen-receptor-positive (ER+) breast cancers. In this study, different plant extracts from Nigella sativa seeds (NSE), Olea europaea Leaves (HTE), Sonchus oleraceus L. (SOE), Mangifera indica Peels (MPE) and Eruca sativa seeds (ESE) were initially prepared. The phytoconstituents of each plant extract were identified and their antioxidant capacities were measured. The Inhibitory properties of these extracts on aromatase activity in human placental microsomes and the IC50s were evaluated. Data showed a concentration-dependent decrease in aromatase activity after treatment with NSE, HTE, MPE and ESE whereas, SOE showed a biphasic effect. Here, The Inhibition kinetic analysis for the most potent inhibitor (NSE) was studied. Moreover, the effects of these extracts on tissue-specific promoter expression of CYP19A1 gene in cell culture model (MCF-7) were assessed using QRT-PCR analysis. Taken together, data revealed from this study are promising to develop a new therapeutic agent against (ER+) breast cancers.