الفهرس 
acknowledgmentOnly 14 pages are availabe for public view
 |  | from | 119 |  |  |
| | | from | 119 | | |
Abstract
Breast cancer is the most common malignant tumor among women worldwide in breast cancer a complex molecular interplay involing multiple signaling pathways including mtor singnaling cyclin Di and B-catenin sinaling have been attributed to the development of this disease exemestane a steroidal that belongs to the third generation of aromatase inhibitors is a mechanism based inhibitor that binds covalently and irreversibly inactiving and destablizing aromatase everolimus afinitor novartis is a sirolimus formerly called rapamycin dervative that inhibits mtor through allosteric binding to mtorc1.