الفهرس 
Introduction and aim of workOnly 14 pages are availabe for public view
 |  | from | 16 |  |  |
| | | from | 16 | | |
Abstract
Background: Thalassemic patients need regular and frequent blood transfusion. So these patients suffer from iron overload and consequently endocrine complication such as hypothyroidism.
Aim of the study: This work was aiming to assess the thyroid dysfunction in Beta- thalassemia major children attending outpatient clinic, Fayoum university hospital to highlight the problem in Fayoum government for early detection and timely treatment of such complication
Subjects and Methods: Across sectional study was conducted to 70 thalassemic patients (5-16 years) who are on regular blood transfusion. Patients are subjected to full history taking , medical examination and laboratory investigation including,complete blood count, serum ferritin level and thyroid function tests .70age and sex matched children without thalassemia constituted the control group.
Results: Four (5.7%) children of the thalassemic patients (70 children) were found to have primary subclinical hypothyroidism. Also there is positive correlation between age of patients(p value <0.001), frequency of blood transfusion (p value <0.01) and developing iron overload and consequently hypothyroidism . For subjects who use iron chelating agents, they still suffer from iron overload and under risk of developing hypothyroidism, so they need closer and more regular follow up.
Conclusion:Hypothyroidism is one of the endocrinopathies that may complicate beta thalassemia major , so regular and close follow up is required for early detection and treatment.