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Abstract Phytochemical and biological studies on certain plants belonging to family Rubiaceae cultivated in Egypt Mussaenda (Rubiaceae) is an important source of medicinal natural products. Mussaenda species are native to the Old World tropics, from West Africa through the Indian sub-continent, South-East Asia and to Southern China (Vidyalakshmi et al., 2009). Some species have been used in Chinese and Fijian traditional medicine (Vidyalakshmi et al., 2009) as a diuretic, antiphlogistic, antipyretic, to detoxify mushroom poisons and to terminate pregnancy in its early months. Non glycosidic iridoids like Mussaein from M. pubesens are cytotoxic (Vidyalakshmi et al. 2008). However, this is the first phytochemical and biological investigation on Mussaenda luteola shrubs. Vangueria edulis (Vahl) Vahl Variety: bainesii Heirn is a small tree, perennial, not exceeds 6 meters in length, known as Spanish tamarind (Wiersema and Leόn, 1999). Nothing could be traced concerning Vangueria edulis except for our previous phytochemical and biological studies on its leaves, this provoked us to investigate its flowers and continue its leaves investigation. The present study was planned to include: Part I: Phytochemical study of Mussaenda luteola aerial parts, including: phytochemical screening, extraction, fractionation, isolation and identification of the constituents of the plant. Part II: Phytochemical study of Vangueria edulis, including: phytochemical screening, extraction, fractionation, isolation and identification of the different constituents of the flowers and leaves Part III: Biological studies on some isolated compounds from the studied plants, including: 1. Opioid and cannabinoid receptors binding assay. 2. Antiprotozoal assay. 3. Antimalarial assay. 4. Antimicrobial assay. 5. MAOIs assay. |