الفهرس 
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Abstract
Chemotherapy induced alopecia (CIA) is one of the most distressing side effects associated with chemotherapy treatments and occasionally can lead to refusal of treatment particularly for women. Scalp cooling is a method of preventing (CIA) by causing vasoconstriction leading to less uptake of drug in the hair follicles, and can also reduce local tissue metabolism. The aim of this study was to determine the efficacy of scalp cooling on the prevention of alopecia in cancer patients undergoing adjuvant chemotherapy. A quasi-experimental research design was used in this study. It was conducted in the Oncology Center at Mansoura University Hospitals. The study sample was a purposive sample of 60 adult female patients, age ranged from >18-60 years old, with cancer and scheduled to be treated with adjuvant chemotherapy for the first time after curative surgery and met the sampling criteria it was divided into 30 subjects in the study group and 30 subjects in the control group, the study group were received scalp cooling while they receiving their chemotherapy cycles while the control group received the routine hospital care. The data collected through the following tools: structure interview questionnaire and physiologic measurement tool of hair loss. Both, study and control group were interviewed and their hair were assessed each time before and after each chemotherapy cycle by using WHO grading system of hair loss, baseline at the first chemotherapy cycle, then the patients interviewed according to their chemotherapy cycle that repeated every 21 days for 6 cycles. The results of this study revealed that there is a good hair preservation and success rate by 86.6% in the scalp cooling group compared to 16.7% in the control group where P=.000. This study concluded that the scalp cooling is effective in the prevention of chemotherapy induced alopecia in cancer patient undergoing adjuvant chemotherapy. This study recommends that the scalp cooling is effective and should be available in the governmental hospitals for the women with cancer and undergoing adjuvant chemotherapy, Further psychological, clinical, and biological research is needed to improve the effect, tolerance, time, and side effect of the cooling procedure.