الفهرس 
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Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a hereditary disease where the body is insufficient of the enzyme glucose-6-phosphate dehydrogenase (G6PD).
Cystatin C is a low molecular weight protein freely filtered by the glomerulus; its serum concentration is less dependent on extra renal factors compared with Creatinine (Cr). It could detect renal dysfunction 1-2 days before Cr.
In the current study, we measured serum cystatin C level in patients with G6PD deficiency aiming to detect glomerular functions impairment in these patients.
Sixty children were included in this study recruited from emergency department and out-patient hematology clinic of pediatric department– El Menia university children hospital during the period from April 2014 to November 2014.
Thirty patients were included, who were clinically and laboratory evaluated as G6PD deficient and were evaluated at time of acute hemolytic crisis (groupIa) and 3m after hemolytic episode (group Ib). Thirty apparently healthy children were included as controls (group II).
All patients were subjected to full medical history taking, detailed clinical examination, abdominal ultrasonography and laboratory investigations including complete blood count, liver enzymes ,serum albumin, blood urea ,serum Cr,urine analysis , microalbuminaria, serum cystatin C and GFR that was calculated by Schwartz formula and Le Bricon equation.
Significant higher serum cystatin C level, serum Creatinine level and A/C ratio and significant lower GFR1 (Creatinine based), GFR2 (measured by serum Cys) was found in group Ia than group II.
Also, significant increase in serum cystatin C level and significant decrease in GFR (2) and GFR1 in group Ib compared to group II. No significant difference regard A/C ratio and serum Creatinine level was observed between these two groups.
There were significant higher serum cystatin C level, serum Creatinine level and A/C ratio and significant lower GFR1 and GFR 2 in group Ia than group Ib.
In group Ia, highly significant negative correlation between serum cystatin C level with G6PD level and significant positive correlation between serum cystatin C level with serum Creatinine level and highly significant positive correlation with retix and A/C ratio.
In group Ib, highly significant negative correlation between serum cystatin C level with G6PD level and highly significant positive correlation between serum cystatin C level with A/C ratio .No any significant correlation between serum cystatin C level with serum Creatinine level nor retix .
There was highly significant positive correlation between A/C ratio with retix, and significant positive correlation with serum Creatinine level in group Ia and no significant correlation with any of them in group Ib.