الفهرس 
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Abstract
Introduction: 25-Hydroxyvitamin D deficiency (<10 ng/ml) is common in patients with chronic kidney disease (CKD) stage 5 (glomerular filtration rate < 15 ml/min/1.73 m2 or on dialysis), but it is unclear if this deficiency is associated with bone disease and other etiological and chemical parameters.
Aim of the work:To study the correlation between vitamin D & bone mineral density,vascular and valvular calcifications& to prove if there is any correlation between vitamin D and other etiological factors
Patients and methods: 40 HD patients (aged 41.12 14.2years) were recruited from a Minia University Hospital dialysis center. Circulating, 25, (OH)2 D, and iPTH,ca &phosphorus were measured. High resolution peripheral quantitative computed tomography (HR-pQCT) was used to measure bone mineral density. MDCT scan was used to detect vascular calcification along the whole course of aorta. Transthoracic echocardiography was used to detect valvular calcifications
Results:The mean vitamin D level was 42.6 ± 33.7 ng/ml . vitamin D was negatively correlated with duration of dialysis (R-0.771, p < 0.001),vascular calcifications(r-0.866, p<0,001)&valvular calcifications(r-0.694, p<0,001). Vitamin D levels were significantly positively correlated with bone mineral density and (R0.964 , p < 0.001). Bone mineral density is negatively correlated with serum iPTH(R-0.796, p<0,001).
Vascular and valvular calcifications prevelance were signficantly higher with low vitamin D level, high BMD range and high iPTH level(p<0.001).
Conclusion: We report that higher vitamin D levels were associated with better bone density, and lesser vascular &valvular calcification. Duration of dialysis is negatively correlated with vitamin D level with no affection of other etiological factors .Negative correlation between BMD and iPTH is also noticed in our researche. Vascular & valvular calcifications are also correlated with iPTH &BMD & vitamin D level. It is imperative that we intensify our efforts to understand the role of vitamin D supplmentation in CKD.