الفهرس 
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Abstract
Febrile seizures (FSs) are the most common type of seizures in children. Their incidence is 2-5% .To date, the pathophysiology of febrile seizures is unknown. But several hypothesis have been purposed that it may relate with plasma iron level and mean platelet volume level.
Objectives: Our objective was to determine the association between iron status and first febrile seizure and to study mean platelet volume as an inflammatory marker in this condition.
Patients and Methods: This prospective case-control study included 90 children hospitalized aged 6 months to 6 years, 45children with the first episode of FS as a case group. The case group was compared to a group of 45 children as a control group admitted to the same ward with the same diagnosis of infection. The control and case groups were matched based on family history of FS, age, sex, temperature and cause of illness. Blood samples were examined for complete blood count (CBC), serum iron, serum ferritin, and total iron-binding capacity (TIBC).
Results: Mean level of ferritin and iron were significantly lower in cases with first febrile seizures than control group, but there were no significant differences between case and control groups in all parameters of CBC; however MPV value is significantly lower in cases with complex febrile seizures than cases with simple febrile seizures.
Conclusion: Plasma ferritin level was significantly lower in children with FFS than in the control group, suggesting a possible role for iron insufficiency in FFS. The lower levels of MPV as an inflammatory marker, supports the idea that CFS is a brain inflammatory disease and the consequence of this inflammatory mechanism is the possibility of development of epilepsy.