الفهرس 
Neonatal sepsisOnly 14 pages are availabe for public view
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Abstract
Septic neonates frequently experience several interventions, including blood transfusions, parentral nutrition, and prescriptions during hospitalization that could affect the result of thyroid function test. This study aims to assess the thyroid hormone and CRP levels in neonates with sepsis and correlating these levels with disease severity and clinical short term outcome among the newborn infants in the neonatal intensive care unit (NICU).
We assessed serum levels of thyroxine and thyroid stimulating hormone of 50 critically full term newborn who were admitted in the NICU, neonatal intensive care unit in the Ain Shams University Hospitals, from 1st of May, 2014 to the end of April, 2015.
A group of septic newborn and a control group (n=100) of healthy non-infected newborns were evaluated. Blood samples were obtained on 3rd day from septic and healthy newborns and on 10th day of the antibiotic therapy from septic group, and thereafter serum total T3 (TT3), total T4 (TT4), and TSH levels was determined.
Our results revealed, that septic neonates on day 3 had, low total T3 with a mean of (58.77 ± 17.07), low total T4 (2.10 ± 2.57) and high TSH levels (6.73 ± 2.08), whereas, on day 10 were, Serum Triiodothyronine (T3) returned to be within the normal range, with a mean of (114.38 ± 26.50), serum thyroxine level (T4) was (11.72 ± 2.54), within the normal range and with increase the TSH level, within the normal range, with a mean of (3.17 ± 2.57).
We determined the relation between T3, serum total thyroxine level and TSH with sex, presence of PROM, CBC, vital signs, CRP, diagnosis of sepsis with positive blood culture, and final outcome (discharge or mortality) were investigated. Short term outcome was considered as being discharge alive from hospital.
TSH level was lower in septic non survivors compared to septic survivors group on both admission (day 3 and day 10) and serum T3 was lower in septic non survivors group compared to septic survivors group in day 3.
Hypothyroxinemia has considerable prevalence in neonatal intensive care setting and is related with critical illness as neonatal sepsis. Whether thyroxin levels are a marker or mediator of short term clinical outcome remains to be determined by further studies.