الفهرس 
English abstractOnly 14 pages are availabe for public view
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Abstract
A total of 120 fish of total length (23±5 cm) and average body weight (257±10g) were
represented as Oreochromis niloticus. They were collected randomly and seasonally. They were examined freshly from western lagoon which is branch from Lake Temsah in Ismailia governorate. The periodic difference of heavy metals concentration based on the data of water samples gathered from western lagoon of the Lake Temsah showed the following result: summer > autumn >winter. The results revealed the presence of metals in the following order: Fe
> Cu >Pb > Zn > Cd. The concentration of heavy metals in fish liver, gills and musculature were always higher than of the water, indicating the bioaccumulation. The highest concentration of heavy metals in water and fish tissue associated with the lowest RBCs count, Hb, PCV, leukocytosis, hypoproteinemia and elevation in serum AST and ALT level than normal. Nevertheless, there is accumulating evidence that some pollutants are immunosuppressive/ weaken fish .In this case, fish may well be more likely to succumb to disease.