الفهرس 
-Dipolar cycloadditionsOnly 14 pages are availabe for public view
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Abstract
In this investigation, two furanone derivatives, one of the 2(3H)-type and the other of the 2(5H)-type, were synthesized and used as starting materials for the construction of other heterocyclic systems of synthetic and biological importance. The original work of this thesis is presented in two parts:
Part (1): Synthesis and reactions of some 2(3H)- and 2(5H)- furanone derivatives: A comparative study
3-Cyano-4,5-diphenyl-2(5H)-furanone 1 and 3-cyano-4,5-diphenyl-2(3H)-furanone 2 were prepared and their reactions with some nitrogen nucleophiles were studied. It was possible to obtain pyrrolone, pyridazinone, thiazolidinone and tetrazole derivatives.
Part (2): Utilization of 4,5- diphenyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile (10) as a precursor of other pyrrole derivatives
The title compound was utilized as a starting material to construct pyrrole derivatives bearing heterocyclic rings at positions -2 and -3. The reactions of this compound with some reagents led to the construction of a thiazolone nucleus at positions -2, a thiazolidinone ring at position -3, and a tetrazole ring at position -3. Also, the thiol group in the starting compound was converted into a sulphonamide group.