الفهرس 
SUBJECT & METHODSOnly 14 pages are availabe for public view
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Abstract
In the Western world Acne vulgaris affects up to 85% of adolescent population, the
prevalence of facial acne vulgaris among teenagers was 67.5%. The condition was more
common among males (71.1%) compared to females (64.6%). Previous studies enquiring
into the potential link between diet and acne vulgaris have shown controversial results.
The relationship between diet and acne is unclear. However, a high glycemic load
diet is associated with worsening acne. There is also a positive association between the
consumption of milk and severity of acne. Other associations such as chocolate and salt are
not supported by the evidence. There may be a relationship between acne and insulin
metabolism and one trial found a relationship between acne and obesity.
High-glycemic-load diets have recently been implicated in acne etiology because of
their ability to increase the insulin demand and other factors associated with insulin
resistance (eg, elevated fatty acids and obesity). Clinical and experimental evidence
suggests that insulin may increase androgen production and affect, through its influence on
steroidogenic enzymes, gonadotrophin releasing hormone secretion and sex hormone–
binding globulin production. Additionally, insulin has been shown to decrease a binding
protein for IGF-I, which may facilitate the effect of IGF-I on cell proliferation. Overall,
these events may influence 1 or more of the 4 underlying causes of acne: 1) increased
proliferation of basal keratinocytes in the pilosebaceous duct, 2) abnormal desquamation of
follicular corneocytes, 3) androgen-mediated increases in sebum production, and 4)
colonization and inflammation of the comedo by Propionibacterium acnes.
This study aimed to study the relationship between dietary intake and levels of
insulin like growth factor -1 with Acne vulgaris among adolescents and adults.
Our subjects divided into two studied groups: Cases group: include adolescents and
adults aged 11-28 years of both sex suffering from acne. Control group: include
adolescents and adults matched with the cases in age and sex but free from acne