الفهرس 
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Abstract
Agricultural and industry discharge water are considered the most dangerous water pollution sources to the River Nile at Greater Cairo. Consequently, the chemical analysis of the water in the River Nile at selected stations as the determination of some heavy metals and pesticides have a great importance to people health. Therefore, the aim of this work was to assess if the changes of the River Nile at Greater Cairo water and fish (Oreochromis niloticus, Tilapia zillii and Clarias gariepinus). The selected stations were before El-Hawamdyia, El-Hawamdyia, after El-Hawamdyia, Shoubra El-Khima, El-Warrak and El-Kanater El-Khyria. The study included water quality, heavy metals (water, sediment and fish), inorganic anions (water, sediment and fish), pesticides distribution (water, sediment and fish) and water microbiology during 2014-2015.The obtained results indicated that the concentrations (water, sediment and fish) of the most chemical parameters heavy metal and inorganic anions increased at stations before El-Hawamdyia, El-Hawamdyia and after El-Hawamdyia and decreased at El-Kanater El-Khyria. Pesticide residues (water, sediment and fish) showed that, chlorpyrifos had most detected amount followed by dicofol, while the lowest amount was carbofuran. Also, our results revealed that 60 % of water samples contaminated with pesticide residues. The chlorinated compound, dicofol was the highest detected pesticide (268.4 ppb), while heptachlor was the most found compound in sediment samples (7 samples). El-Kanater El-Khyria site have the higher amount of pesticide residues (123.5 ppb) during winter season compare to the other sites for sediment. Also, reported that the concentrations of all pesticides were observed to be higher than the European Union (EU) set maximum residue limits (MRLs) and Acceptable Daily Intake (ADI). Clarias gariepinus had the largest residual amount (485.6 ppb) compare to the Oreochromis niloticus (364.9 ppb) and Tilapia zillii (338.4ppb). Microbiological studies showed that there were some contaminations distributed at all sides with coliform, Escherichia coli pathogenic strains and Faecal streptococci. Hoosier Riverwatch Water Quality Index showed that, the highest values were recorded in winter season at Shoubra El-Khima, and it was (WQI = 73.79 and WQR= GOOD), while the minimum value recorded in summer at El-Hawamdyia and it was (WQI = 57.72 and WQR= MEDIUM). Key words: Water quality, pollution, water resources, heavy metals, sediment, Oreochromis niloticus, Tilapia zillii, Clarias gariepinus, pesticides.