الفهرس 
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Abstract
This study was designed to evaluate the canine amniotic membrane (AM) as biological dressing for deep ulcerated cutaneouse wound artificially induced in rabbits at different stages of wound healing and highlight its effect on oxidative stress indicators and antioxidant status in serum and wound granulation tissue and the concentration of hydroxy proline in wound tissue. Collection of AM from healthy full term pregnant bitch for further processing and preservation procedures. 27 New Zealand white male rabbits were divided into three groups (group І that was dressed by AM, group ІІ that was dressed by Pividone iodine and group ІІІ that was kept untreated as control group and all were subjected for wound induction) .serum samples were collected at 7 days post wounding for evaluation of oxidative stress markers while tissue specimens were collected at 7, 14 and 21 days post wounding for histopathological and immunohistochemical evaluation. Results revealed that wounds that was dress by AM showed reduction in oxidative stress indicators , elevation in hydroxy proline content , promotion of wound healing and contraction, rapid epithelization and compared with the other groups.