الفهرس 
Patients and MethodsOnly 14 pages are availabe for public view
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Abstract
In critically ill newborns, failure of one or multiple organ systems is frequently seen due to inadequate circulation to the tissues.
An early mechanism in the cascade of events leading to cell damage or death is that the cell membrane starts to leak intracellular components, such as lactate dehydrogenase, into plasma.
Lactate dehydrogenase (LDH) is a cytoplasmatic enzyme present essentially in all major organ systems including the Heart, muscles ,liver, red and white blood cells, lungs, kidneys, stomach, pancreas, brain, and cancer cells.
Recently, plasma LDH, using a cut-off value of 1050 U⁄L, has been shown to be a good predictor of hypoxic ischemic encephalopathy (HIE) in a group of infants showing signs of fetal distress during birth.
Early suspicion of upcoming disease in a newborn and prompt referral for adequate work up and treatment would reduce mortality and permanent damage and consequently improve the overall outcome.
The aim of this study was to evaluate the relationship between the early clinical course of neonatal intensive care unit infants and LDH in plasma at admission.
This study which was held in Shebin El Kom Teaching Hospital during a period of 5 weeks beginning at the end of February 2014, on Fifty neonates who were admitted to the NICU of from whom data were recorded in a special form and were statically analyzed .
In the study, all patients were subjected to detailed medical history, full clinical examination, and laboratory investigations including.