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Abstract 1. The thesis startes with an introduction covering a general review for the chemistry of 2,6-pyridinedicarboxylic acid (dipicolinic acid) till 1997. It includes also a special part presenting the obtained results followed by the experimental part and ended with a list of 280 references. 2. The thesis includes a course of investigation to synthesize a series of some peptide derivatives. Coupling of 2,6-pyridine dipicolinoyl dichloride (23) with amino acid methyl esters to afford 2,6-bis (aminocarbonyl)pyridine methyl ester derivatives (125) was preformed followed by treating with hydrazine hydrate to give the corresponding dihydrazide derivatives (126). . o (’nNI o NH O 0 _R a a b_H _CO_O_M_e ., R’t’NH ’NH!R Ao o o NAy TEA (23) o I I CH3 CH3 (125) (126) 3. Some dihydrazone derivatives (127) have been prepared from the reaction of the diydrazide derivatives (126) with benzaldehyde or p-chlorobenzaldehyde. (127) 4- Hydrolysis of diesters (125) with sodium hydroxide gave the corresponding diacid derivatives (128). 0 (128) 5- Dihydrazide derivatives (88) and (126) reacted with some acid · anhydrides to give the corresponding diamide-(129) and tetraamidediimide derivatives (130), respectively. (129) (130) 6. Condensation of dihydrazides (88) and (126) with some tetra carboxylic acid dianhydrides, namely I ,2,4,5-benzenetetra carboxylic acid dianhydride or I ,4,5,8-naphthalenetetracarboxylic acid dianhydride was undertaken to afford different macrocyclic polyamide derivatives (131) and (132), respectively. 0y-”N-”y0 0y-”N-”y0 :a:a : oNu_;o( oNu_;o( (131a) (131b) |