الفهرس 
Epidemiology of Uterine LeiomyomasOnly 14 pages are availabe for public view
 |  | from | 32 |  |  |
| | | from | 32 | | |
Abstract
This study was done to evaluate the possible relation
between the age of patients, size and multiplicity of
fibroids to Estrogen Receptors (ER) and Epidermal Growth
Factor Receptors (EGFR) expression in the myometrium of the
fibroids which were excised, in a trial to evaluate the relation
of these receptors and the growth pattern of uterine fibroid
tumor.
The study was carried out on Fifty patients who were
attending Ain Shams Maternity Hospital.
They were divided into two age groups, the 1st group
:::;35 years old while the 2nd group >35 years old:
• The 151 group:::; 35 years old underwent myomectomy.
• The 2”d group> 35 years old underwent myomectomy or
hysterectomy.
They underwent surgery for symptomatic uterine
fibroids.
All patients where subjected to history taking including:
• Personal history including age, parity.
• Menstrual history including last menstrual cycle.
• Contraceptive history over last 3-6 months before the
study.
• Present history including pain, swelling and abnormal
bleeding.
• Past history including any medical disorder. • Family history including any medical disorder.
• Clinical examination with proper assessment.
• Ultrasonographic investigations.
All patients were postmenstrual and none of them had taken any hormonal preparation 6 months before
the study was done.
The study is an immuno-histochemical study, which was conducted in cooperation with the ”Early
cancer detection unit” at Ain Shams University Maternity Hospital.
After pathological examination, tissue samples ofthe myomas were collected for immuno-histochemical
study for Estrogen Receptor (ER) & Epidermal Growth Factor Receptor
(EGFR) assay.
As regards the relationship between the age and the size of the fibroids, it was noticed that there
is a high statistical significance, which indicates the presence of a relationship between the age
and the size of the fibroids.
As regards the relationship between the age and the multiplicity of the fibroids, it was noticed
that there is a high statistical significance, which indicates the presence of a relationship
between the age and the multiplicity of the
fibroids.
As regards the relationship between the parity and the multiplicity of the fibroids, it was noticed
that there is no statistical significance between the parity and the multiplicity of the
fibroids, which indicates the absence of a relationship between the parity and the multiplicity of
the fibroids.
As regards the relationship between the parity and the size of the fibroids, it was noticed that
there is no statistical significance between the parity and the size of the fibroids, which
indicates the absence of a relationship between the parity and the size of the fibroids.
As regards the relationship between the size of the fibroids and degeneration, it was noticed that
there is high statistical significance between the size of the fibroid and degeneration, which
indicates the presence of a relationship between the size of the fibroids and degeneration.
As regards Estrogen Receptors expression:
It was found that there was no statistical significance correlation between the age and ER
expression when compared between the two groups.
Also when concerning the relationship between the parity & ER expression, there was no statistical
significance correlation.
However, it was found that ER expression is higher in multiparous women.
But when concerning the relationship between the multiplicity of the fibroids & ER expression,
there was a statistical significance correlation, where it was found that ER expression is higher
in single fibroid than in multiple ones.
As regards the relationship between size of the fibroid and ER expression, there was no
statistical significance correlation.
However, it was found that ER expression is higher in large sized fibroids than in smaller ones.