الفهرس 
Non traditional risk factorsOnly 14 pages are availabe for public view
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Abstract
CAD has become the commonest cause of death in the
world. Risk factor identification is extremely important in prediction or even prevention of
such serious disease.
Several methods have been suggested to screen for CAD, some of these methods are relatively
invasive with potential risks. So the presence of a simple marker which could detect the risk for
CAD, without being invasive, would be very beneficial. Recent trends to non traditional risk
factors such as homocystein as an independent risk factor and its role in CAD
The aim of this study was to measure the incidence of hyperhomocysteinemia in a group of Egyptian
ischaemic males and its correlation to the number of diseased vessels.
Ninety five Egyptian male subjects were chosen for this study. Eighty were documented by CA to
have CAD were 15 control subjects.
According to the number of the diseased vessels documented by coronary angiography the diseased
subjects were divided into three groups. Arterial blood samples were collected after an overnight
fast for 14 hours. Lipid profile and tHey were measured.
Wilcoxon Rank Sum test was used for comparison between each two groups while One Way ANOVA was used
for simultaneous comparison between the diseased groups and correlation study was done.Comparing the control group with the single vessel
disease group, marked overlap of the results was observed and hence no significant
statistical difference in the tHey
level was detected.
Whereas a lesser degree of overlap could be exhibited when the control was compared to the two
vessels disease group but a significantly higher tHey in the diseased group was detected.
Comparing the three vessels disease group to the control group little overlap in the results was
observed and the statistical difference in the total plasma tHey levels was highly significant in
the diseased group.
Some overlap in the results and hence no significant statistical difference was detected when the
two vessels disease group is compared to the single and the three vessels disease groups.
Although some overlap in the results was detected when the single and the three vessel disease
groups were compared together, significantly higher tHey level was observed in the latter group.
When the three groups compared together regarding the tHey, a climbing up pattern of the results
was observed but no significant statistical difference between the compared groups could be
obtained. But the whole diseased population exhibited a significantly higher tHey when compared to
the control group.
In the present study tHey could not be correlated to other risk factors or any ofthe assayed
parameters among the control group and all the diseased groups.
In conclusion, The tHey incidence among the diseased group in the present study was found to be 17%
which is an indication that it is an important risk factor in CAD. Whereas the presence of a
climbing up pattern in the level of tHey among the diseased group and failure to correlate that
elevation to any other risk factor suggests that hyperhomocysteinemia is an in dependant risk
factor for CAD in the studied group.
Although tHey exhibited a climbing up pattern in the present study among the diseased groups it
can’t be used for diagnosis or grading of CAD due to the relatively low sensitivity and specificity
reported in the present study.
Risk factor modification is very important to prevent or at least alter the disease process
especially in CAD when the risk factors are reversible or at least controllable. So, further
research may be needed to clarify if the use of vitamin supplementation affects the CAD process.