الفهرس 
2-INTERLE U KIN-SOnly 14 pages are availabe for public view
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Abstract
Two asthmatic groups each included 20 patients,
the asymptomatic group where patients were free of symptoms, the symptomatic group whei·e patients
were suffering fi-om acute exacerbation of their asthma and both of asthmatic groups were
subclassilicd into mild and moderate subgroups each of I 0 patients according asthma severity. All
subjects were subjected to clinical study, chest X-ray for subclassification of patients, peak
expiratory flow rate (PEFR) recording for sub classification of patients, skin prick testing using
common allergens (patients only) and laboratory investigations which included complete blood count
(CBC) including absolute eosinophil count (AEC), urine and stool examination, total serum lgE
level, plasma IL-8 level and plasma endothelin-1 level. There was no significant difference between
the study groups as regards AEC. There was a highly significant elevation in serum lgE of the
asthmatic groups in comparison to control group. There was a highly significant elevation in plasma
endothclin-1 and plasma IL-8 levels of the symptomatic asthmatic subgroups in con1parison to
control group and asymptomatic asthmatic subgroups. In conclusion: despite this profile, a causal
link between IL-8, ET-1 and asthma has not been definitively established, but surely, it is now
clear that those mediators, their receptors, synthesis and degradation pathways oiler potentially
important therapeutic targets.