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العنوان
Effect of some Natural Product on Hepatic Ischemia /Reperfusion-Induced Injury in Rats /
المؤلف
Ghamry, Marwa ElSayed Mohamed Nasr.
هيئة الاعداد
باحث / مروه السيد محمد نصر غمري
مشرف / أحمد فهمي أحمد
مشرف / شيماء مصطفي الشاذلي
مناقش / أحمد فهمي أحمد
الموضوع
Natural Products - Therapeutic use.
تاريخ النشر
2015.
عدد الصفحات
179 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
العلوم الصيدلية
الناشر
تاريخ الإجازة
1/1/2015
مكان الإجازة
جامعة الزقازيق - كــليـــة الصيدلــــة - فارماكولوجى
الفهرس
Only 14 pages are availabe for public view

from 192

from 192

Abstract

Hepatic ischemia/reperfusion (I/R) injury is an inevitable event during many clinical situations including liver trauma and is intended during liver surgeries to minimize bleeding. It is believed that I/R-mediated hepatic injury has been resulted from both oxidative stress mediators including reactive oxygen/nitrogen species and also from the release of pro-inflammatory cytokines.
The present investigation was carried out to clarify the hepatoprotective effect, antioxidant and anti-inflammatory role of some natural products particularly (Curcumin, 11-keto-BA and Ginkgo biloba) against hepatic I/R-induced injury in improving the liver status through measuring selected parameters such as:
1. Liver function tests: ALT, AST and LDH activities.
2. Pro-inflammatory cytokines: TNF-α.
3. Hepatic GSH content.
4. Hepatic lipid peroxides content: (measured as MDA).
5. Hepatic NO content: measured as nitrate/nitrite.
6. Hepatic iNOS expression.
7. Hepatic platelet activating factor & platelet aggregation.