الفهرس 
.CancerOnly 14 pages are availabe for public view
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Abstract
A diminished amount of antioxidant enzyme coupled with superoxideproduction in appears to be general characteristic of the tumor cells. This character can be used in cancer treatment.Thus the present study attempted to investigate the effect of Thiosemicarbazide- cobalt complex which have SOD like activity on tumor development using Hepatocellular carcinoma cells (HepG2) implemented in Swiss albino female mice.
Accordingly, the mice were classified into five groups of ten animals in each group as follows: group 1; normal mice injected with 0.9 % NaCl saline solution. group 2; normal mice injected with complex solvent (Di-methyl sulphoxide).G3; normal mice injected with cobalt complex. group 4; Hepatocellularcarcinoma cells(HepG2) induced mice injected with 0.9 % NaCl saline solution. group 5;Hepatocellular carcinoma cells (HepG2) treated with cobalt complex.
The following parameters were determined:
1. Life span prolongation of the tumor-induced mice which would evidence theantitumor activity of cobalt complex.
2. Serum creatinine, Hb, GPT, and GOT were carried out as parameter to drug toxicity and follow the clinical status of the treated animals as well as its extent of responsiveness to treatment.
3. The Nitric oxide, MDA and the activities of antioxidant and glutathionerelated enzyme activity as well as the reduced glutathione content which would partly highlight the mode of action of the tested complexes.