الفهرس 
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Abstract
The present thesis comprises the following chapters:Chapter 1 (Introduction and Literature Review): An introduction described describing
the diabetes mellitus, different approaches for control, nuclear PPARs,
transmembranal GPCR40/FFAR1, design of both receptor ligands and the advantage
of multivariable functional ligands in managing diabetes mellitus. Study aim of
developing PPAR-γ/FFAR1 co-agonists.
Chapter 2 (Scientific Rational): Our strategy on incorporating the structural features
of glitazones with GPCRs’ privileged structures through a simple linker.
Chapter 3 (Results and Discussions): A theoretical discussion for synthetic pathways
and their mechanisms, applied in the 7 schemes, to obtain the final new compounds.
A correlation between the chemical structures of novel compounds and obtained
biological activities molecular docking studies.
Chapter 4 (Experimental Protocols): The present investigation involves the synthesis
of 76 intermediates. In addition to, the synthesis and characterization of the final 30
compounds.
References: A list of 554 references which were used and their arrangement
according to their order in the thesis.
Appendix: The 1H-NMR and 13C-NMR of all the compounds synthesized for this
work.