الفهرس 
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Abstract
Two asthmatic groups each included 20 patients, the asymptomatic group where patients were free of
symptoms, the symptomatic group whei·e patients were suffering fi-om acute exacerbation of their
asthma and both of asthmatic groups were subclassilicd into mild and moderate subgroups each of I 0
patients according asthma severity. All subjects were subjected to clinical study, chest X-ray for
subclassification of patients, peak expiratory flow rate (PEFR) recording for sub classification
of patients, skin prick testing using common allergens (patients only) and laboratory
investigations which included complete blood count (CBC) including absolute eosinophil count (AEC),
urine and stool examination, total serum lgE level, plasma IL-8 level and plasma endothelin-1
level. There was no significant difference between the study groups as regards AEC. There was a
highly significant elevation in serum lgE of the asthmatic groups in comparison to control group.
There was a highly significant elevation in plasma endothclin-1 and plasma IL-8 levels of the
symptomatic asthmatic subgroups in con1parison to control group and asymptomatic asthmatic
subgroups. In conclusion: despite this profile, a causal link between IL-8, ET-1 and asthma has
not been definitively established, but surely, it is now clear that those mediators, their
receptors, synthesis and degradation pathways oiler potentially important therapeutic targets.