الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Giant cell tumor (GCT) of bone is a relatively common bone neoplasm. Such tumor is characterized by being unique as regards its microscopic appearance as well as its future behavior.
GCT affects young adults, commonly in their extremities, particulary in bones around the knee. This tumor has the ability to destroy native bone and causes soft tissue invasion such local aggressiveness is the cause of the large cavity encountered commonly
after GCT’s curettage.
A major problem faced by the orthopedist during GCT’s patients management is their unpredictable picture behaviors.
GCT may recur following treatment in more than 52% of cases after curettage. It may metastasize in up to 6%of cases, especially to the lungs. Such potentially for recurrence or metastasis can not be known prospectively through clinical evaluation, histopathological examination, flow cytometric studies or even cytogenetics.
Enneking staging system which intergrades clinical, radiological and microscopic data are claimed to be helpful in prediction ofGCT’s biological behavior. Also Campanacci’s radiological grading, which merely needs xray picture of the tumor of good quality, is claimed to be useful in knowing future of GCT as well.
Though Enneking staging system and Campanacci’s radiological grading seem to be helpful, an additional tool is still needed to solve this problem radically.