الفهرس 
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Abstract
This study was carried out to evaluate the effectiveness of platelet rich fibrin (PRF) on healing after surgical extraction of the impacted mandibular third molars.
This study was conducted on 20 adult patients with an age range of 20 to 30 years having mesioangular position B impacted mandibular third molars indicated for surgical extraction. They were selected from the Out-Patient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University.
The patients were divided into two groups
• Control group: Composed of 10 patients whose empty sockets were left to heal without any interference.
• Study group: Composed of 10 patients, where PRF was applied in the extraction sockets of the mandibular third molar.
Postoperative antibiotic and analgesics were prescribed. All patients were instructed to apply ice bags extra orally for 20 minutes/hour, five times on the day of operation only. Proper oral hygiene was maintained by using a warm antiseptic mouth wash starting on the second post-operative day and lasting for a week. The sutures were removed after 7 days.
The post-operative evaluation was performed both clinically and radiographically.
Clinical evaluation
It was performed to evaluate:
• Pain and edema using the visual analogue scale on the second, fourth and seventh postoperative days.
• Trismus using a caliber applied between the upper central incisors and the lower central incisors at the midline preoperatively and on the second, fourth and seventh postoperative days.
Radiographic evaluation
It was performed to evaluate the bone height and bone density at the site of the extraction using image processing program (Image J program).
• Bone height: Was digitally measured from the cement-enamel junction (CEJ) to the alveolar bone crest (ABC) on the distal aspect of the mandibular second molars preoperatively and after one, two and three months post-operatively.
• Bone density: was recorded after one, two and three months post-operatively.
This study showed less pain in the study group than in the control group on the second, fourth and seventh days post operatively but the difference was not significant.
There was significantly less swelling in the study group than in the control group on the second and fourth post-operative days. Post-operative trismus was also less pronounced in the study group than in the control group although the difference was not significant.
There was significant increase in the bone height and density in study group than in the control group after two and three months postoperatively.
from this study, it is clear that PRF is considered a good material for bone fill and therapeutic agent of choice in the treatment of bone defect sites.