الفهرس 
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Abstract
The aim of bone healing is to restore the integrity of the bone by production of new bone at the site of injury. Dentin chips has an effect on bone healing when implanted in bone defect. Aim of the work: This study was conducted to identify the effects of dentin chips with prednisolon and / or neomycin on mandibular bone defect healing in guinea pigs by histological and immunohistochemical methods using IL-6 antibody. This study was carried out on 60 adult male guinea pigs. All animals underwent surgical bone defects and divided into 5 groups: group I: act as a control and underwent bone defect without treatment. group II: bone defect filled with dentin chips. group III: bone defect filled with dentin chips mixed with prednisolone. group IV: bone defect filled with dentin chips mixed with neomycin. group V: bone defect filled with dentin chips mixed with prednisolone and neomycin. At the end of experiment, the animals were sacrificed and processed for: 1- Hematoxylin and eosin staining. 2- Immunohistochemical staining using interleukin- 6 antibody. The Immunohistochemical staining were assessed and scored. The results of this study were analyzed statistically by SPSS using two way ANOVA. Results: A- Hematoxylin and eosin results: group I: granulation tissue mixed with thin bone trabeculae filled the cavity. group II: bone trabeculae were formed adjacent to the dentin pieces with gradual resorption of dentin chips. group III: high cellular density with some bone trabeculae formed around dentin chips. group IV: increase amount of collagen fibers around dentin chips with some bone trabeculae formation. group V: large mass of tissue may be bone could be seen inside the Cavity. B- Immunohistochemical results: Dentin chips groups revealed the most expressive results of IL-6 while other groups vary in intensity of IL- 6 expression.