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Abstract All surgical procedures are associated with neuroendocrine response and pain stimulation. Inadequate treated pain results in many adverse effects which can affect the quality of life. In cesarean delivery, there is a special concern to postoperative pain management for helping mother and her infant.This study was designed to evaluate the effect of addition of ketamine to bupivacaine in transversus abdominis plane block after cesarean section as regarding the analgesic efficacy and duration and postoperative opioid consumption.Fifty patients undergoing elective cesarean delivery were randomized into two groups:Bupivacaine group and Bupivacaine-ketamine group.Visual analogue scale exhibited no statistical significance between the bupivacaine and bupivacaine-ketamine group. Also, fentanyl consumption demonstrated no significant difference. Postoperative nausea and vomiting showed increase in the incidence in bupivacaine- ketamine group. Sedation score increased significantly in bupivacaine – ketamine group.The finding of this study revealed that addition of ketamine 0.5mg/kg to bupivacaine 0.25 % in 40 ml total solution in TAP block after cesarean delivery did not provide additional effect on postoperative analgesia when compared to bupivacaine alone. |