الفهرس 
Chapter II: Review of literatureOnly 14 pages are availabe for public view
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Abstract
Objectives: Carbon tetrachloride (CCl4) is one of the most dangerous hepatotoxic environmental pollutants thus this study aimed to investigate the potential therapeutic role of Plantago major (PM) and Moringa oleifera (MO) as medicinal plants with their antioxidant properties against CCl4-induced hepatotoxicity in rat model.
Methods: Seventy female albino rats were divided into 7 equal groups. One group of rats was fed on basal diet and kept as a negative control. Also, the 2nd group was injected i.p. with 0.5 ml/kg olive oil and kept as olive oil group while three groups were intoxicated i.p. with CCl4 at a dose of 0.5 ml /kg body weight mixed in olive oil (v/v), twice a week for 8 weeks. The first group of the intoxicated rats was left as a positive control while the others were oral administrated with PM and MO extract at a dose of 200 and 400 mg/kg, respectively and other two groups were gives only 250,400 mg/kg of PM and MO extract, respectively. At the end of experimental period (8 weeks), the rats were sacrificed and blood samples were collected for biochemical analyses. Livers of the sacrificed rats were removed, weighted and processed for histopathological examination.
Results: CCl4 induced significant (p < 0.05), increase in relative liver weight to body weight, blood MDA content, and liver function tests (ALT, AST, and ALP). In addition, CCl4 induced significant decrease in albumin, total proteins, cholesterol, triglycerides, total lipids, RBCs, WBCs, Hgb and HCT and in the activities of SOD, CAT, TAC and GSH content. Also, CCl4 disturbed liver histology. Furthermore, either P. major or M. oleifera administration can counteract CCl4-disturbed parameters and preserved liver histology close to normal.
Conclusion: Plantago major and Moringa oleifera leaves extract enhanced innate antioxidant activity and ameliorate the CCl4-induced liver injury and therefore can be used as hepatoprotective drugs in the future.