الفهرس 
Nodular, noduloulcerative basal cell carcinomaOnly 14 pages are availabe for public view
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Abstract
Basal-cell carcinomas make up 80% of all skin cancers and are the
most common malignant disease in white populations [256]. The incidence of
basal-cell carcinoma is increasing worldwide up to 10% per year, and is
also increasing in young people [257].
Basal cell carcinoma is locally invasive, with slowly spreading growth
which rarely metastasize, arising in the epidermis or hair follicles and in
which, in particular, the peripheral cells usually simulate the basal cells of
the epidermis [257]. BCCs occurs most frequently at sun-exposed sites, with
the head and neck being the common areas and more precisely develops on
the face with the nose and lip most commonly affected [235].
CXCR4 is a rhodopsin-like seven-transmembrane G-protein coupled
receptor that exclusively binds to CXCL12 [258]. CXCL12–CXCR4 axis
plays an important role in multiple biological processes[259] and is also
involved in cancers and in organ-specific metastasis. Therefore, the receptor
can represent a valuable therapeutic target for multiple diseases such as
inflammation, cancer, and HIV/AIDS [260].
β.