الفهرس 
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Abstract
After the liver and lung, bone is the third most common site
of metastases. Eighty percent of all bone metastases are secondary
to breast, prostate, and lung carcinomas.
Cancer cells metastasize to bone almost exclusively via
hematogenous spread, although this may also result via direct
extension of tumor. Bone metastases are generally classified into
two types. Osteoblastic metastases are characterized by the
deposition of new bone via increased osteoblastic activity,
whereas osteolytic metastases are characterized by the destruction
of normal bone via increased osteoclastic activity. Metastatic
lesions can contain both components.