الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Reactive oxygen species are byproducts of normal metabolism and have roles in cell signaling, immunity and homeostasis. Mechanisms exist to regulate cellular levels of reactive oxygen species, as their reactive nature may otherwise cause damage to key cellular components including DNA, protein, and lipid. When the cellular antioxidant capacity is exceeded, oxidative stress can result
Pleiotropic deleterious effects of oxidative stress are observed in numerous disease states and are also implicated in a variety of drug-induced toxicities. Well-characterized drugs associated with adverse events to which oxidative stress may contribute, including examples of cancer therapies, non-steroidal anti-inflammatory drugs (NSAID), antiretroviral agents, antipsychotics, analgesics and aminoglycosides antibiotics.
The current study was outlined to look into drug-induced oxidative stress. giving an example of its consequences (renal failure), hopefully seeking a possible way out through the use of antioxidant vitamine C.
Fifty six adult albino rats weighing 150-200 g were allocated into seven groups , Eight rats each as follow:
The 1st group:
Rats in this group were left as control.