الفهرس 
Pathophysiology of MigraineOnly 14 pages are availabe for public view
 |  | from | 115 |  |  |
| | | from | 115 | | |
Abstract
Migraine is a common episodic neurovascular disorder characterized by recurrent attacks of typically throbbing, unilateral, and often severe headache with associated features such as nausea, vomiting and hypersensitivity to light, sound and smell. In one-third of migraines, the headache is preceded by transient neurological symptoms (visual, motor or somatosensory) lasting for up to an hour or sometimes for several days and known as an aura (Vecchia et al., 2012).
The current study was conducted at Ain Shams University Hospitals during the period between January 2015 and June 2016. Eighty subjects were enrolled in this study divided into two groups: Case group including 40 patients with migraine. Control group including 40 age and sex matched healthy individuals.
Patients with migraine showed a statistically significant thinning in RNFL (in all quadrants except for the nasal quadrant), a significant thinning in GCL (in superior and inferior parts), a significant thinning of the choroid in the nasal and temporal quadrants only, and significant thickening in the superior quadrant of choroid.
The comparison between patients with aura and those without aura as regards OCT parameters revealed that choroid (in all its parts) was thicker among the patients with aura when compared to the patients without aura.
Correlation was done between the duration of illness and the severity of migraine (using MIDAS) which showed that the duration of illness was inversely correlated with the thickness of the GCL and the choroid (superior, inferior and temporal quadrants). The severity of migraine was inversely correlated with the thickness of the temporal quadrant of RNFL and inferior part of GCL.