الفهرس 
Acute Myeloid LeukemiaOnly 14 pages are availabe for public view
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Abstract
Acute myeloid leukemia (AML) represents a group of biologically heterogeneous clonal proliferation of undifferentiated myeloid precursor cells with diverse clinical and biological features. Detection of HLA-G expression at diagnosis is of high clinical relevance, because its expression has a direct consequence for treatment stratification, being associated with poor prognosis. The present study planned to assess HLA-G expression in AML in relation to clinical and some laboratory parameters and to evaluate its prognostic impact on patient’s survival &disease outcome. The current study was carried out on 30 newly diagnosed AML patients. All patients were subjected to complete history taking, thorough clinical examination and laboratory investigations including: complete blood picture, bone marrow aspiration with examination of Leishman-stained peripheral blood and bone marrow smears and detection of the level of HLA-G expression by real time PCR Concerning the clinical outcome of the studied patients, HLA-G positive patients showed more incidences of relapse and death than HLA-G negative patients, while HLA-G negative patients were more liable to achieve complete remission. Finally, these findings imply that HLA-G is an independent prognostic factor for clinical outcome and response to chemotherapy.