الفهرس 
Normal LaborOnly 14 pages are availabe for public view
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Abstract
Background: Labor is defined as the onset of regular contractions and cervical change. It is traditionally divided into three stages. The first stage encompasses the onset of labor to the complete dilatation of the cervix, and is subdivided into latent and active phases. The active phase begins when the rate of cervical dilatation accelerates, which occurs at 4 cm on average.
Aims: This study aims to assess the effect of hyoscine versus drotaverine on the course of labor among primigravida women were managed according to the standard intrapartum protocols.
Methodology: This randomized placebo-controlled double-blind trial was conducted at the labor and delivery unit of Ain Shams university maternity hospital after being approved by the local institutional ethics and research committee. Enrollment for this study commenced in January 2016 and was completed in August 2016.
Results: A total number of 231 patients were enrolled in the study. The eligible participated patients were randomized into 3 groups, 77 patient in each. Eight patients were excluded from the analysis (1 patient from hyoscine group, 5 patients from drotaverine group and 2 patients from placebo group) as they delivered by caesarian section. Therefore, a total of 223 patients had completed data available for analysis.
Conclusion: The use of drotaverine hydrochloride (Do-Spa) during labor management has been associated with a statistically significant reduction in the duration of first stage of labor (=244.8 min) by increasing the rate of cervical dilatation (= 1.6 cm/h) than hyoscine N-butyl bromide.
Recommendations: from this study, it is recommended to use drotaverine hydrochloride intravenously as an adjuvant therapy in labor management of primiparous women to decrease the duration of labor, labor pain and to increase the rate of cervical dilatation.