الفهرس 
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Abstract
s
In this work, efforts have been directed toward developing new
synthetic routes for synthesis of 4-substituted-2-phenyl oxazolones as
precursors to variety of azole and azine derivatives of expected
biological activities. The newly synthesized derivatives were obtained
on subjecting the 5-oxzaolones to ring transformation under varieties of
reagents and reaction conditions which could effect their
rearrangements.
A new facial route for synthesis of 4-arylideneoxazolones 2a-m
is presented. In this methodology, arylmethylene malononitriles 1 were
utilized as a trans-arylidene reagent on their reaction with hippuric acid.
The reaction sequence takes place via Tandem Michael addition/retro
Michael reaction with extrusion of malononitrile. The procedure
constitutes a general fashion since the reaction was amenable to a
variety of ylidene malononitriles extended from that derived from
aromatic aldehydes to that derived from acyclic and cyclic ketones and
ketoesters.